BAIT

UHRF2

NIRF, RNF107, URF2, RP11-472F14.2
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UPS Project
Homo sapiens
PREY

HSPA1L

HSP70-1L, HSP70-HOM, HSP70T, hum70t, DADB-333F21.5
heat shock 70kDa protein 1-like
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.

Liu Y, Zhang B, Kuang H, Korakavi G, Lu LY, Yu X

5-Hydroxymethylcytosine (5hmC) is an epigenetic modification that is generated by ten-eleven translocation (TET) protein-mediated oxidation of 5-methylcytosine (5mC). 5hmC is associated with transcription regulation and is decreased in many cancers including melanoma. Accumulating evidence has suggested that 5hmC is functionally distinct from 5mC. Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) is the first known specific 5hmC reader that ... [more]

J. Biol. Chem. Jun. 24, 2016; 291(26);13679-88 [Pubmed: 27129234]

Throughput

  • High Throughput

Curated By

  • BioGRID