BAIT
HSD17B10
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, RP3-339A18.2
hydroxysteroid (17-beta) dehydrogenase 10
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GPX1
AI195024, AL033363, CGPx, GPx-1, GSHPx-1, Gpx
glutathione peroxidase 1
GO Process (46)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- UV protection [ISO]
- angiogenesis involved in wound healing [IMP]
- apoptotic process [IMP]
- blood vessel endothelial cell migration [IMP]
- cell proliferation [IMP]
- cell redox homeostasis [ISO]
- endothelial cell development [IMP]
- fat cell differentiation [IMP]
- glutathione metabolic process [ISO]
- heart contraction [IMP, ISO]
- hydrogen peroxide catabolic process [IMP, ISO]
- interaction with symbiont [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- lipid metabolic process [IMP]
- myoblast proliferation [IMP]
- myotube differentiation [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of inflammatory response to antigenic stimulus [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- oxidation-reduction process [ISO]
- positive regulation of protein kinase B signaling [IMP]
- protein oxidation [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of mammary gland epithelial cell proliferation [ISO]
- regulation of neuron apoptotic process [IMP]
- regulation of proteasomal protein catabolic process [ISO]
- response to gamma radiation [IGI]
- response to hydrogen peroxide [IMP, ISO]
- response to hydroperoxide [IMP]
- response to lipid hydroperoxide [ISO]
- response to oxidative stress [IGI, IMP]
- response to reactive oxygen species [IMP]
- response to selenium ion [ISO]
- response to symbiotic bacterium [IGI]
- response to toxic substance [IMP]
- response to wounding [IMP]
- response to xenobiotic stimulus [IMP]
- sensory perception of sound [IMP]
- skeletal muscle fiber development [IMP]
- skeletal muscle tissue regeneration [IMP]
- temperature homeostasis [IGI]
- triglyceride metabolic process [IMP]
- vasodilation [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient patients and adding SCHAD to the list of mitochondrial proteins capable of forming functional, multi-pathway complexes. In this work, we provide evidence of SCHAD's involvement ... [more]
PLoS ONE Apr. 13, 2012; 7(4);e35048 [Pubmed: 22496890]
Throughput
- Low Throughput
Curated By
- BioGRID