BAIT
HSD17B10
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, RP3-339A18.2
hydroxysteroid (17-beta) dehydrogenase 10
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRDX5
AOEB166, AOPP, Pmp20, Prdx6, PrxV
peroxiredoxin 5
GO Process (11)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- NADPH oxidation [ISO]
- cellular response to reactive oxygen species [ISO]
- hydrogen peroxide catabolic process [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of oxidoreductase activity [ISO]
- negative regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of collagen biosynthetic process [ISO]
- reactive nitrogen species metabolic process [ISO]
- regulation of apoptosis involved in tissue homeostasis [ISO]
- response to oxidative stress [ISO, ISS]
Gene Ontology Molecular Function- RNA polymerase III regulatory region DNA binding [ISO]
- antioxidant activity [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- peroxidase activity [ISO]
- peroxiredoxin activity [ISO]
- peroxynitrite reductase activity [ISO]
- protein dimerization activity [ISO]
- receptor binding [ISO, ISS]
- RNA polymerase III regulatory region DNA binding [ISO]
- antioxidant activity [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- peroxidase activity [ISO]
- peroxiredoxin activity [ISO]
- peroxynitrite reductase activity [ISO]
- protein dimerization activity [ISO]
- receptor binding [ISO, ISS]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient patients and adding SCHAD to the list of mitochondrial proteins capable of forming functional, multi-pathway complexes. In this work, we provide evidence of SCHAD's involvement ... [more]
PLoS ONE Apr. 13, 2012; 7(4);e35048 [Pubmed: 22496890]
Throughput
- Low Throughput
Curated By
- BioGRID