BAIT
HSD17B10
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, RP3-339A18.2
hydroxysteroid (17-beta) dehydrogenase 10
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACAA2
0610011L04Rik, AI255831, AI265397, D18Ertd240e
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISO]
- cellular response to hypoxia [ISO]
- fatty acid beta-oxidation [ISO]
- negative regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient patients and adding SCHAD to the list of mitochondrial proteins capable of forming functional, multi-pathway complexes. In this work, we provide evidence of SCHAD's involvement ... [more]
PLoS ONE Apr. 13, 2012; 7(4);e35048 [Pubmed: 22496890]
Throughput
- Low Throughput
Curated By
- BioGRID