BAIT
CAV1
Cav, Cav-1
caveolin 1, caveolae protein
GO Process (89)
GO Function (15)
GO Component (28)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- T cell costimulation [ISO]
- angiogenesis [IGI]
- apoptotic signaling pathway [ISO]
- calcium ion homeostasis [IMP]
- calcium ion transport [IMP]
- caveola assembly [IMP, ISO]
- caveolin-mediated endocytosis [ISO]
- cellular calcium ion homeostasis [IMP, ISO]
- cellular response to hyperoxia [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IMP]
- cellular senescence [ISO]
- cholesterol efflux [ISO]
- cholesterol homeostasis [IMP]
- cytosolic calcium ion homeostasis [ISO]
- endocytosis [TAS]
- inactivation of MAPK activity [IMP]
- lactation [IMP]
- lipid storage [IMP]
- maintenance of protein location in cell [ISO]
- mammary gland development [IMP]
- mammary gland involution [IMP]
- membrane depolarization [IMP]
- microtubule polymerization [ISO]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of JAK-STAT cascade [IDA, IGI, IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of anoikis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cation channel activity [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytokine-mediated signaling pathway [IMP]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of nitric oxide biosynthetic process [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-tyrosine autophosphorylation [ISO]
- negative regulation of pinocytosis [ISO]
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of protein ubiquitination [IMP, ISO]
- negative regulation of signal transduction [IDA]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IDA, IMP]
- nitric oxide homeostasis [IMP]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of peptidase activity [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of signal transduction [ISO]
- positive regulation of vasoconstriction [IMP, ISO]
- protein homooligomerization [IDA]
- protein localization [IMP]
- protein oligomerization [IDA]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of blood coagulation [ISO]
- regulation of fatty acid metabolic process [IMP]
- regulation of inward rectifier potassium channel activity [ISO]
- regulation of membrane repolarization during action potential [ISO]
- regulation of peptidase activity [IMP]
- regulation of smooth muscle contraction [IMP]
- regulation of the force of heart contraction [IMP]
- regulation of the force of heart contraction by chemical signal [IGI]
- response to calcium ion [IDA]
- response to estrogen [IDA, ISO]
- response to hypoxia [IMP]
- response to ischemia [IMP]
- response to mechanical stimulus [ISO]
- response to progesterone [ISO]
- skeletal muscle tissue development [IMP]
- triglyceride metabolic process [IMP]
- vasculogenesis [IMP]
- vasoconstriction [IMP]
- vesicle organization [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [ISO]
- RNA polymerase I transcription factor binding [ISO]
- SNARE binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel inhibitor activity [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- nitric-oxide synthase binding [ISO]
- peptidase activator activity [IMP]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [ISO]
- structural molecule activity [ISO]
- syntaxin binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- RNA polymerase I transcription factor binding [ISO]
- SNARE binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- inward rectifier potassium channel inhibitor activity [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- nitric-oxide synthase binding [ISO]
- peptidase activator activity [IMP]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [ISO]
- structural molecule activity [ISO]
- syntaxin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [ISO]
- acrosomal membrane [IDA]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- caveola [IDA, ISO, TAS]
- cell [IMP]
- cell cortex [IDA]
- cell surface [ISO]
- cilium [IDA]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO]
- endosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [IDA]
- integral component of plasma membrane [IDA]
- intracellular [IMP, ISO]
- lipid particle [ISO]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrion [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- peroxisomal membrane [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IPI, ISO]
Mus musculus
PREY
PARK2
PRKN
Parkinson disease (autosomal recessive, juvenile) 2, parkin
GO Process (48)
GO Function (21)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- aggresome assembly [ISO]
- cellular protein catabolic process [ISO]
- cellular response to toxic substance [ISO]
- dopamine metabolic process [IMP]
- dopamine uptake involved in synaptic transmission [IMP]
- learning [IMP]
- locomotory behavior [IMP]
- mitochondrion degradation [ISO]
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of cell death [ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of glucokinase activity [ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of oxidative stress-induced neuron death [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- norepinephrine metabolic process [IMP]
- positive regulation of DNA binding [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of mitochondrial fusion [ISO]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein linear polyubiquitination [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein metabolic process [IMP]
- protein monoubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of autophagy [ISO]
- regulation of mitochondrion organization [ISO]
- regulation of neurotransmitter secretion [IMP]
- regulation of reactive oxygen species metabolic process [ISO]
- regulation of synaptic transmission [IMP]
- response to endoplasmic reticulum stress [ISO]
- response to unfolded protein [ISO]
- startle response [IMP]
- synaptic transmission, dopaminergic [IMP]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- F-box domain binding [ISO]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO]
- PDZ domain binding [ISO]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- tubulin binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- ubiquitin-specific protease binding [ISO]
- F-box domain binding [ISO]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO]
- PDZ domain binding [ISO]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- tubulin binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi membrane [ISO]
- LUBAC complex [ISO]
- Parkin-FBXW7-Cul1 ubiquitin ligase complex [ISO]
- aggresome [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [ISO]
- intracellular [ISO]
- membrane raft [ISO]
- mitochondrion [ISO]
- neuron projection [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
- protein complex [IDA]
- synapse [ISO]
- synaptic vesicle [ISO]
- ubiquitin ligase complex [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.
Parkinson's disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. While most PD is sporadic in nature, a significant subset can be linked to either autosomal dominant or recessive mutations. PARK2, encoding the E3 ubiquitin ligase, parkin, is the most frequently mutated gene in autosomal recessive early onset PD. It has recently been reported ... [more]
Mol Neurodegener Dec. 03, 2015; 10(0);63 [Pubmed: 26627850]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARK2 CAV1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1521718 | |
| PARK2 CAV1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 1521720 |
Curated By
- BioGRID