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BAIT

NLGN3

HNL3

neuroligin 3

GO Process (20)

GO Function (5)

GO Component (6)

Gene Ontology Biological Process

adult behavior [IMP]

axon extension [ISS]

metabolic process [IBA]

neuron cell-cell adhesion [IBA, ISS]

positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]

positive regulation of excitatory postsynaptic membrane potential [ISS]

positive regulation of synapse assembly [ISS]

positive regulation of synaptic transmission, glutamatergic [ISS]

postsynaptic membrane assembly [ISS]

presynaptic membrane assembly [ISS]

receptor-mediated endocytosis [ISS]

regulation of inhibitory postsynaptic membrane potential [ISS]

regulation of respiratory gaseous exchange by neurological system process [ISS]

regulation of synaptic transmission [IBA, ISS]

rhythmic synaptic transmission [ISS]

social behavior [IMP]

synapse assembly [IBA, ISS]

synapse organization [IMP]

vocalization behavior [IMP]

Gene Ontology Molecular Function

carboxylic ester hydrolase activity [IBA]
cell adhesion molecule binding [ISS]
neurexin family protein binding [IBA, ISS]
protein binding [IPI]
receptor activity [IBA, ISS]

Gene Ontology Cellular Component

cell surface [IDA]

endocytic vesicle [ISS]

excitatory synapse [IDA]

extracellular space [IBA]

integral component of plasma membrane [IBA, ISS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PLCB4

ARCND2, PI-PLC, RP4-811H13.1

phospholipase C, beta 4

GO Process (2)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

inositol phosphate metabolic process [TAS]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

phospholipase C activity [TAS]

Gene Ontology Cellular Component

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism.

Shen C, Huo LR, Zhao XL, Wang PR, Zhong N

Autism is a neurodevelopmental disorder with a strong genetic predisposition. Neurolign 3 (NLGN3) as a postsynaptic transmembrane protein, functions in both neuron synaptogenesis and glia-neuron communications. Previously, a gain of function mutation (R451C) in NLGN3 was identified in autistic patients, which illustrates the involvement of NLGN3 in autism pathogenesis. As proper synaptic targeting and functioning are controlled by intracellular protein ... [more]

J. Mol. Neurosci. May. 01, 2015; 56(1);89-101 [Pubmed: 25464930]

Throughput

Low Throughput

Curated By

BioGRID