BAIT
NLGN3
HNL3
neuroligin 3
GO Process (20)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- adult behavior [IMP]
- axon extension [ISS]
- learning [IMP]
- metabolic process [IBA]
- neuron cell-cell adhesion [IBA, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- receptor-mediated endocytosis [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISS]
- regulation of synaptic transmission [IBA, ISS]
- rhythmic synaptic transmission [ISS]
- social behavior [IMP]
- synapse assembly [IBA, ISS]
- synapse organization [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP2A2
ADTAB, CLAPA2, HIP-9, HIP9, HYPJ
adaptor-related protein complex 2, alpha 2 subunit
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism.
Autism is a neurodevelopmental disorder with a strong genetic predisposition. Neurolign 3 (NLGN3) as a postsynaptic transmembrane protein, functions in both neuron synaptogenesis and glia-neuron communications. Previously, a gain of function mutation (R451C) in NLGN3 was identified in autistic patients, which illustrates the involvement of NLGN3 in autism pathogenesis. As proper synaptic targeting and functioning are controlled by intracellular protein ... [more]
J. Mol. Neurosci. May. 01, 2015; 56(1);89-101 [Pubmed: 25464930]
Throughput
- Low Throughput
Curated By
- BioGRID