Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism.

Shen C, Huo LR, Zhao XL, Wang PR, Zhong N

Autism is a neurodevelopmental disorder with a strong genetic predisposition. Neurolign 3 (NLGN3) as a postsynaptic transmembrane protein, functions in both neuron synaptogenesis and glia-neuron communications. Previously, a gain of function mutation (R451C) in NLGN3 was identified in autistic patients, which illustrates the involvement of NLGN3 in autism pathogenesis. As proper synaptic targeting and functioning are controlled by intracellular protein ... [more]

J. Mol. Neurosci. May. 01, 2015; 56(1);89-101 [Pubmed: 25464930]

Throughput

  • Low Throughput

Curated By

  • BioGRID