BAIT
RNF216
2810055G22Rik, AI647468, AU019462, C86502, F830018F18Rik, TRIAD3, UIP83, Ubce7ip1
ring finger protein 216
GO Process (4)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Mus musculus
PREY
UBE2L3
C79827, UbcM4, Ubce7
ubiquitin-conjugating enzyme E2L 3
GO Process (11)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cell cycle phase transition [ISO]
- cell proliferation [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to steroid hormone stimulus [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein K11-linked ubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Triad3A regulates synaptic strength by ubiquitination of Arc.
Activity-dependent gene transcription and protein synthesis underlie many forms of learning-related synaptic plasticity. At excitatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic activity to postsynaptic endocytosis of AMPA-type glutamate receptors. Although the mechanisms for Arc induction have been described, little is known regarding the molecular machinery that terminates Arc function. Here, we demonstrate that the RING domain ... [more]
Neuron Jun. 18, 2014; 82(6);1299-316 [Pubmed: 24945773]
Throughput
- Low Throughput
Additional Notes
- E2:UbcH7
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBE2L3 RNF216 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID