ITGB3
Gene Ontology Biological Process
- activation of protein kinase activity [ISO]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- cell adhesion [ISO]
- cell growth [ISO]
- cell migration [ISO]
- cell projection morphogenesis [IC]
- cell-matrix adhesion [IGI, ISO]
- cell-substrate adhesion [ISO]
- cell-substrate junction assembly [IDA]
- cellular calcium ion homeostasis [ISO]
- heterotypic cell-cell adhesion [ISO]
- integrin-mediated signaling pathway [ISO]
- negative chemotaxis [ISO]
- negative regulation of cell death [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of lipoprotein metabolic process [ISO]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- platelet activation [ISO]
- platelet aggregation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of bone resorption [IC, ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of glomerular mesangial cell proliferation [ISO]
- positive regulation of leukocyte migration [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of osteoclast differentiation [IC]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein folding [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell migration [IMP]
- regulation of release of sequestered calcium ion into cytosol [ISO]
- smooth muscle cell migration [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- viral entry into host cell [ISO]
Gene Ontology Molecular Function- cell adhesion molecule binding [ISO]
- extracellular matrix binding [ISO]
- fibrinogen binding [ISO]
- fibronectin binding [ISO]
- identical protein binding [ISO]
- integrin binding [IPI]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein disulfide isomerase activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- cell adhesion molecule binding [ISO]
- extracellular matrix binding [ISO]
- fibrinogen binding [ISO]
- fibronectin binding [ISO]
- identical protein binding [ISO]
- integrin binding [IPI]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein disulfide isomerase activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- alpha9-beta1 integrin-ADAM8 complex [IDA]
- apical plasma membrane [IDA, ISO]
- cell surface [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- integrin alpha9-beta1 complex [TAS]
- integrin alphav-beta3 complex [ISO]
- integrin complex [ISO]
- lamellipodium membrane [ISO]
- melanosome [ISO]
- membrane [ISO]
- microvillus membrane [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
PRKCB
Gene Ontology Biological Process
- B cell activation [IMP]
- B cell receptor signaling pathway [IMP]
- calcium ion transport [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to carbohydrate stimulus [IDA]
- histone H3-T6 phosphorylation [ISO]
- negative regulation of glucose transport [IMP]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of B cell receptor signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- protein phosphorylation [IDA]
- regulation of dopamine secretion [ISO]
- regulation of growth [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to drug [ISO]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium channel regulator activity [IDA]
- chromatin binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-T6 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [IDA]
- androgen receptor binding [ISO]
- calcium channel regulator activity [IDA]
- chromatin binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-T6 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets.
Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) catalyzes release of arachidonic acid from glycerophospholipids, leading to thromboxane A(2) (TxA(2)) production. Some platelet agonists stimulate cPLA(2)alpha, but others require fibrinogen binding to alphaIIbbeta3 to elicit TxA(2). Therefore, relationships between cPLA(2)alpha and alphaIIbbeta3 were examined. cPLA(2)alpha and a cPLA(2)alpha binding partner, vimentin, coimmunoprecipitated with alphaIIbbeta3 from platelets, independent of fibrinogen binding. Studies with ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Curated By
- BioGRID