BAIT
NSE3
SPCC645.04
Smc5-6 complex non-SMC subunit Nse3
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RQH1
hus2, rad12, rec9, SPAC2G11.12
RecQ type DNA helicase Rqh1
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IGI]
- intra-S DNA damage checkpoint [IDA]
- maintenance of rDNA [IMP]
- mitotic DNA replication DNA duplex unwinding [ISO]
- negative regulation of mitotic recombination [IMP]
- postreplication repair [IMP]
- recombinational repair [IGI]
- regulation of mitotic recombination involved in replication fork processing [IMP]
- replication fork processing at rDNA locus [IGI]
- resolution of mitotic recombination intermediates [IMP]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.
SMC5/6 is a highly conserved protein complex related to cohesin and condensin, which are the key components of higher-order chromatin structures. The SMC5/6 complex is essential for proliferation in yeast and is involved in replication fork stability and processing. However, the precise mechanism of action of SMC5/6 is not known. Here we present evidence that the NSE1/NSE3/NSE4 sub-complex of SMC5/6 ... [more]
Nucleic Acids Res. Feb. 18, 2016; 44(3);1064-79 [Pubmed: 26446992]
Throughput
- Low Throughput
Curated By
- BioGRID