NR3C1
Gene Ontology Biological Process
- adrenal gland development [IMP]
- cellular response to dexamethasone stimulus [ISO]
- cellular response to steroid hormone stimulus [ISO]
- chromatin remodeling [ISO]
- chromatin-mediated maintenance of transcription [ISO]
- glucocorticoid mediated signaling pathway [IDA]
- glucocorticoid metabolic process [IMP]
- glucocorticoid receptor signaling pathway [IDA, IMP, ISO]
- mammary gland duct morphogenesis [IMP]
- maternal behavior [IGI]
- negative regulation of glucocorticoid mediated signaling pathway [IDA]
- negative regulation of synaptic plasticity [ISO]
- negative regulation of vascular permeability [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of neuron apoptotic process [IGI]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of cell proliferation [ISO]
- regulation of glucocorticoid biosynthetic process [IMP]
- regulation of gluconeogenesis [IMP]
- regulation of glucose metabolic process [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to arsenic-containing substance [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- Hsp70 protein binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- glucocorticoid receptor activity [IDA]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [ISO]
- heat shock protein binding [ISO]
- hormone binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IDA]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor tyrosine kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- steroid binding [ISO]
- steroid hormone binding [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- DNA binding [IDA]
- Hsp70 protein binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- glucocorticoid receptor activity [IDA]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [ISO]
- heat shock protein binding [ISO]
- hormone binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IDA]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor tyrosine kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- steroid binding [ISO]
- steroid hormone binding [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
FKBP5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
Glucocorticoid receptor (GR) is cytoplasmic in the absence of ligand and localizes to the nucleus after steroid binding. Previous evidence demonstrated that the hsp90-based heterocomplex bound to GR is required for the efficient retrotransport of the receptor to the nuclear compartment. We examined the putative association of GR and its associated chaperone heterocomplex with structures of the nuclear pore. We ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Curated By
- BioGRID