BAIT
SERPINB5
PI5, maspin
serpin peptidase inhibitor, clade B (ovalbumin), member 5
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EEF1A1
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2
eukaryotic translation elongation factor 1 alpha 1
GO Process (5)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Evidence for a direct interaction between the tumor suppressor serpin, maspin, and types I and III collagen.
Maspin (mammary serine protease inhibitor) was originally identified as a tumor suppressor protein in human breast epithelial cells and is a member of the serine proteases inhibitor (serpin) superfamily. It inhibits tumor cell motility and angiogenesis, and although predominantly cytoplasmic, it is also localized to the cell surface. In this study we have investigated the use of the yeast two-hybrid ... [more]
J. Biol. Chem. Mar. 29, 2002; 277(13);10783-8 [Pubmed: 11788595]
Throughput
- Low Throughput
Additional Notes
- Figure 2
Curated By
- BioGRID