BAIT
SHANK3
AI841104, SHANK3c-3, SHANK3c-4, Shank3b
SH3/ankyrin domain gene 3
GO Process (33)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- MAPK cascade [IGI]
- N-methyl-D-aspartate receptor clustering [IMP]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- brain morphogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- embryonic epithelial tube formation [IGI]
- guanylate kinase-associated protein clustering [IMP]
- learning [IMP, ISO]
- locomotory exploration behavior [IMP]
- memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell volume [IMP]
- neuromuscular process controlling balance [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of synapse structural plasticity [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density assembly [IMP]
- protein oligomerization [ISO]
- regulation of behavioral fear response [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of grooming behavior [IMP]
- regulation of long term synaptic depression [IMP]
- regulation of long-term synaptic potentiation [IMP]
- social behavior [IMP, ISO]
- striatal medium spiny neuron differentiation [IMP]
- synapse assembly [IMP]
- vocal learning [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAPGEF2
5830453M24Rik, CNRasGEF, Pdzgef1, RA-GEF-1, mKIAA0313, nRapGEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (32)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- Rap protein signal transduction [ISO]
- adenylate cyclase-activating adrenergic receptor signaling pathway [ISO]
- blood vessel development [IMP]
- brain-derived neurotrophic factor receptor signaling pathway [ISO]
- cAMP-mediated signaling [IDA, ISO]
- cellular response to cAMP [IDA, IMP, ISO]
- cellular response to cGMP [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- establishment of endothelial barrier [ISO]
- forebrain neuron development [IMP]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of dendrite morphogenesis [IMP, ISO]
- negative regulation of melanin biosynthetic process [IMP]
- nerve growth factor signaling pathway [ISO]
- neuron migration [IMP]
- neuron projection development [IMP, ISO]
- neuropeptide signaling pathway [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of Rap GTPase activity [IDA, IMP, ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of cAMP-dependent protein kinase activity [IMP, ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of dendritic cell apoptotic process [IMP, ISO]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein binding [IDA]
- positive regulation of protein kinase activity [IDA, ISO]
- positive regulation of vasculogenesis [IMP]
- regulation of cell junction assembly [ISO]
- regulation of synaptic plasticity [ISO]
- ventricular system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.
The postsynaptic site of neurons is composed of more than 1500 proteins arranged in protein-protein interaction complexes, the composition of which is modulated by protein phosphorylation through the actions of complex signaling networks. Components of these networks function as key regulators of synaptic plasticity, in particular hippocampal long-term potentiation (LTP). The postsynaptic density (PSD) is a complex multicomponent structure that ... [more]
Sci Signal Aug. 11, 2016; 9(440);rs8 [Pubmed: 27507650]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHANK3 RAPGEF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2334076 |
Curated By
- BioGRID