SHANK3
Gene Ontology Biological Process
- MAPK cascade [IGI]
- N-methyl-D-aspartate receptor clustering [IMP]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- brain morphogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- embryonic epithelial tube formation [IGI]
- guanylate kinase-associated protein clustering [IMP]
- learning [IMP, ISO]
- locomotory exploration behavior [IMP]
- memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell volume [IMP]
- neuromuscular process controlling balance [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of synapse structural plasticity [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density assembly [IMP]
- protein oligomerization [ISO]
- regulation of behavioral fear response [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of grooming behavior [IMP]
- regulation of long term synaptic depression [IMP]
- regulation of long-term synaptic potentiation [IMP]
- social behavior [IMP, ISO]
- striatal medium spiny neuron differentiation [IMP]
- synapse assembly [IMP]
- vocal learning [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHANK1
Gene Ontology Biological Process
- adult behavior [ISO]
- associative learning [IMP]
- dendritic spine morphogenesis [IMP]
- determination of affect [ISO]
- habituation [IMP]
- long-term memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- neuromuscular process controlling balance [IMP]
- olfactory behavior [IMP]
- positive regulation of dendritic spine development [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- protein complex assembly [ISO]
- protein localization to synapse [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- righting reflex [IMP]
- social behavior [IMP, ISO]
- synapse maturation [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [IMP, ISO]
- SH3 domain binding [ISO]
- ankyrin repeat binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein complex binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- scaffold protein binding [ISO]
- somatostatin receptor binding [ISO]
- GKAP/Homer scaffold activity [IMP, ISO]
- SH3 domain binding [ISO]
- ankyrin repeat binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein complex binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- scaffold protein binding [ISO]
- somatostatin receptor binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISO]
- dendrite [IDA]
- dendritic spine [IDA, ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [IDA]
- membrane [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [IDA]
- plasma membrane [IDA]
- postsynaptic membrane [IDA, ISO]
- synapse [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.
The postsynaptic site of neurons is composed of more than 1500 proteins arranged in protein-protein interaction complexes, the composition of which is modulated by protein phosphorylation through the actions of complex signaling networks. Components of these networks function as key regulators of synaptic plasticity, in particular hippocampal long-term potentiation (LTP). The postsynaptic density (PSD) is a complex multicomponent structure that ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SHANK3 SHANK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2334082 | |
SHANK3 SHANK1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.4385 | BioGRID | 3499767 |
Curated By
- BioGRID