BAIT
DLG4
Dlgh4, PSD-95, PSD95, SAP90, SAP90A, RP23-172M21.9
discs, large homolog 4 (Drosophila)
GO Process (23)
GO Function (18)
GO Component (24)
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IBA, ISO]
- dendritic spine morphogenesis [IDA, ISO]
- establishment of protein localization [ISO]
- locomotory behavior [NAS]
- locomotory exploration behavior [IMP]
- negative regulation of receptor internalization [ISO]
- neuromuscular process controlling balance [IMP]
- nucleotide phosphorylation [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- protein complex assembly [ISO]
- protein localization to synapse [IDA, ISO]
- receptor localization to synapse [IBA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of grooming behavior [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of neuronal synaptic plasticity [NAS]
- response to cocaine [NAS]
- signal transduction [IBA]
- social behavior [IMP]
- synaptic vesicle maturation [IDA, IGI]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- cell junction [IDA]
- cerebellar mossy fiber [IDA]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- ionotropic glutamate receptor complex [IDA]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [IDA]
- neuron spine [IDA]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [IDA]
- synaptic vesicle [IDA]
- voltage-gated potassium channel complex [ISO]
Mus musculus
PREY
DLG1
B130052P05Rik, Dlgh1, E-dlg/SAP97, SAP-97, SAP97, mKIAA4187
discs, large homolog 1 (Drosophila)
GO Process (40)
GO Function (13)
GO Component (32)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell cytokine production [IMP]
- actin filament organization [ISO]
- activation of protein kinase activity [IMP]
- amyloid precursor protein metabolic process [IGI]
- branching involved in ureteric bud morphogenesis [IMP]
- cortical actin cytoskeleton organization [ISO]
- embryonic skeletal system morphogenesis [IMP]
- endothelial cell proliferation [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [IBA]
- hard palate development [IMP]
- immunological synapse formation [IMP]
- lens development in camera-type eye [IMP]
- membrane raft organization [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein kinase B signaling [IMP]
- nucleotide phosphorylation [IBA]
- peristalsis [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of developmental growth [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of potassium ion transport [ISO]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [ISO]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- regulation of membrane potential [IGI, ISO]
- regulation of myelination [IMP]
- regulation of protein localization [ISO]
- reproductive structure development [IMP]
- single organismal cell-cell adhesion [ISO]
- smooth muscle tissue development [IMP]
- synaptic transmission [IBA]
- tight junction assembly [ISO]
- tissue morphogenesis [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [ISO]
- basal lamina [IDA]
- basal plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO, TAS]
- cell junction [IDA, ISO]
- cell projection membrane [IDA]
- cell-cell adherens junction [TAS]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- ionotropic glutamate receptor complex [IBA]
- lateral loop [IDA]
- lateral plasma membrane [IDA]
- membrane raft [IDA]
- microtubule [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- node of Ranvier [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA]
- presynaptic membrane [ISO]
- synapse [IDA]
- tight junction [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.
The postsynaptic site of neurons is composed of more than 1500 proteins arranged in protein-protein interaction complexes, the composition of which is modulated by protein phosphorylation through the actions of complex signaling networks. Components of these networks function as key regulators of synaptic plasticity, in particular hippocampal long-term potentiation (LTP). The postsynaptic density (PSD) is a complex multicomponent structure that ... [more]
Sci Signal Aug. 11, 2016; 9(440);rs8 [Pubmed: 27507650]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLG4 DLG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low/High | - | BioGRID | 2333672 | |
| DLG4 DLG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| DLG4 DLG1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.7465 | BioGRID | 2668602 | |
| DLG4 DLG1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.5063 | BioGRID | 3498545 |
Curated By
- BioGRID