SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADAM9
Gene Ontology Biological Process
- PMA-inducible membrane protein ectodomain proteolysis [ISO]
- activation of MAPKK activity [ISO]
- cell adhesion [ISO]
- cell adhesion mediated by integrin [ISO]
- cell-matrix adhesion [ISO]
- cellular response to lipopolysaccharide [ISO]
- membrane protein ectodomain proteolysis [IDA, ISO]
- monocyte activation [ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of keratinocyte migration [ISO]
- positive regulation of macrophage fusion [ISO]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of protein secretion [ISO]
- response to calcium ion [ISO]
- response to glucocorticoid [IMP]
- response to hydrogen peroxide [ISO]
- response to manganese ion [ISO]
- response to tumor necrosis factor [ISO]
- transforming growth factor beta receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.
The postsynaptic site of neurons is composed of more than 1500 proteins arranged in protein-protein interaction complexes, the composition of which is modulated by protein phosphorylation through the actions of complex signaling networks. Components of these networks function as key regulators of synaptic plasticity, in particular hippocampal long-term potentiation (LTP). The postsynaptic density (PSD) is a complex multicomponent structure that ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNGAP1 ADAM9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343606 | |
SYNGAP1 ADAM9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333229 |
Curated By
- BioGRID