SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIA1
Gene Ontology Biological Process
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- long term synaptic depression [IGI]
- long-term memory [IMP, ISO]
- neuronal action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor internalization [IMP, ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to toxic substance [ISO]
- synaptic transmission [IGI]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- axonal spine [IDA]
- cell surface [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendrite membrane [IDA]
- dendritic shaft [ISO]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- ionotropic glutamate receptor complex [IDA]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- protein complex [ISO]
- recycling endosome [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.
The postsynaptic site of neurons is composed of more than 1500 proteins arranged in protein-protein interaction complexes, the composition of which is modulated by protein phosphorylation through the actions of complex signaling networks. Components of these networks function as key regulators of synaptic plasticity, in particular hippocampal long-term potentiation (LTP). The postsynaptic density (PSD) is a complex multicomponent structure that ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNGAP1 GRIA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343643 | |
SYNGAP1 GRIA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333285 |
Curated By
- BioGRID