PEBP1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of acetylcholine metabolic process [ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of mitosis [ISO]
- regulation of neurotransmitter levels [ISO]
- regulation of the force of heart contraction [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- apical part of cell [ISO]
- axon terminus [ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- rough endoplasmic reticulum [ISO]
- synaptic vesicle [ISO]
RAF1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPKK activity [ISO]
- cell differentiation [IGI]
- death-inducing signaling complex assembly [IMP]
- intermediate filament cytoskeleton organization [IMP]
- intracellular signal transduction [TAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- negative regulation of protein complex assembly [ISO]
- neurotrophin TRK receptor signaling pathway [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [ISO, TAS]
- response to hypoxia [ISO]
- response to muscle stretch [IMP]
- somatic stem cell maintenance [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase kinase kinase activity [ISO]
- Ras GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [ISO]
- ATP binding [ISO]
- MAP kinase kinase kinase activity [ISO]
- Ras GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.
It was demonstrated previously that a positive feedback loop, including protein kinase C (PKC) and mitogen-activated protein kinase (MAPK), is required for the gradual expression of cerebellar long-term depression (LTD). PKC and MAPK are mutually activated in this loop. MAPK-dependent PKC activation is likely to be mediated by phospholipase A2. On the other hand, it is not clear how PKC ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 6
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAF1 PEBP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1527638 |
Curated By
- BioGRID