BAIT
FOXL2
AU045128, BPES, PINTO, Pfrk
forkhead box L2
GO Process (15)
GO Function (9)
GO Component (1)
Gene Ontology Biological Process
- apoptotic DNA fragmentation [ISO]
- embryonic eye morphogenesis [IMP]
- extraocular skeletal muscle development [ISO]
- female somatic sex determination [IMP]
- granulosa cell differentiation [IMP]
- menstruation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISO]
- ovarian follicle development [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [TAS]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- cysteine-type endopeptidase regulator activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- ubiquitin conjugating enzyme binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- cysteine-type endopeptidase regulator activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- ubiquitin conjugating enzyme binding [ISO]
Mus musculus
PREY
RPL4
2010004J23Rik
ribosomal protein L4
GO Process (0)
GO Function (2)
GO Component (9)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles.
FOXL2 transcription factor is responsible for the Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES), a genetic disease involving craniofacial malformations often associated with ovarian failure. Recently, a somatic FOXL2 mutation (p.C134W) has been reported in >95% of adult-type granulosa cell tumors. Here, we have identified 10 novel FOXL2 partners by yeast-two-hybrid screening and co-immunoprecipitation. Most BPES-inducing mutated FOXL2 proteins display aggregation ... [more]
Hum. Mol. Genet. Jul. 15, 2012; 21(14);3264-74 [Pubmed: 22544055]
Throughput
- Low Throughput
Additional Notes
- FOXL2 mutant p.H104N
- Table S1
- source of Foxl2 unclear
Curated By
- BioGRID