FOXL2
Gene Ontology Biological Process
- apoptotic DNA fragmentation [IMP]
- cell differentiation [NAS]
- extraocular skeletal muscle development [IMP]
- menstruation [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- ovarian follicle development [IMP, ISS]
- positive regulation of apoptotic process [IGI, IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function- DNA binding [IDA, TAS]
- cysteine-type endopeptidase regulator activity involved in apoptotic process [IMP]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- ubiquitin conjugating enzyme binding [IPI]
- DNA binding [IDA, TAS]
- cysteine-type endopeptidase regulator activity involved in apoptotic process [IMP]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- ubiquitin conjugating enzyme binding [IPI]
CXXC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles.
FOXL2 transcription factor is responsible for the Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES), a genetic disease involving craniofacial malformations often associated with ovarian failure. Recently, a somatic FOXL2 mutation (p.C134W) has been reported in >95% of adult-type granulosa cell tumors. Here, we have identified 10 novel FOXL2 partners by yeast-two-hybrid screening and co-immunoprecipitation. Most BPES-inducing mutated FOXL2 proteins display aggregation ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 1
Curated By
- BioGRID