CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
GGT1
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular amino acid metabolic process [TAS]
- cysteine biosynthetic process [ISS]
- glutamate metabolic process [IDA]
- glutathione biosynthetic process [ISS, TAS]
- glutathione catabolic process [IDA]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [TAS]
- leukotriene biosynthetic process [IMP]
- leukotriene metabolic process [TAS]
- regulation of immune system process [ISS]
- regulation of inflammatory response [ISS]
- small molecule metabolic process [TAS]
- spermatogenesis [ISS]
- xenobiotic metabolic process [TAS]
- zymogen activation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95.
γ-Glutamyl transpeptidase (GGT) is a heterodimeric membrane enzyme that catalyzes the cleavage of extracellular glutathione and other γ-glutamyl-containing compounds. GGT is synthesized as a single polypeptide (propeptide) that undergoes autocatalytic cleavage, which results in the formation of the large and small subunits that compose the mature enzyme. GGT is extensively N-glycosylated, yet the functional consequences of this modification are unclear. ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID