ARRB1
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [IDA]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [TAS]
- endocytosis [IDA]
- follicle-stimulating hormone signaling pathway [IDA]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of GTPase activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of receptor internalization [ISO, ISS]
- positive regulation of smooth muscle cell apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IDA, ISO, TAS]
- regulation of cAMP biosynthetic process [TAS]
- regulation of cAMP catabolic process [TAS]
- sensory perception of pain [TAS]
- sensory perception of touch [TAS]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
PDE4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
cAMP-specific PDE (phosphodiesterase) 4 isoforms underpin compartmentalized cAMP signalling in mammalian cells through targeting to specific signalling complexes. Their importance is apparent as PDE4 selective inhibitors exert profound anti-inflammatory effects and act as cognitive enhancers. The p38 MAPK (mitogen-activated protein kinase) signalling cascade is a key signal transduction pathway involved in the control of cellular immune, inflammatory and stress responses. ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 7
Curated By
- BioGRID