FOXO1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to DNA damage stimulus [ISS]
- cellular response to cold [ISS]
- cellular response to hyperoxia [IDA]
- cellular response to insulin stimulus [ISS]
- cellular response to nitric oxide [ISS]
- cellular response to oxidative stress [ISS]
- cellular response to starvation [IDA, ISS]
- endocrine pancreas development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fat cell differentiation [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of apoptotic process [IMP]
- positive regulation of autophagy [IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein acetylation [ISS]
- regulation of energy homeostasis [ISS]
- temperature homeostasis [ISS]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function
PRKACA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- carbohydrate metabolic process [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular response to epinephrine stimulus [TAS]
- cellular response to glucagon stimulus [TAS]
- cellular response to glucose stimulus [IDA]
- cytosolic calcium ion homeostasis [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- mitotic cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of cell cycle arrest [ISS]
- protein phosphorylation [NAS]
- regulation of cardiac muscle contraction [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [TAS]
- regulation of heart rate [TAS]
- regulation of insulin secretion [TAS]
- regulation of osteoblast differentiation [IDA]
- regulation of proteasomal protein catabolic process [IDA]
- regulation of protein binding [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- regulation of tight junction assembly [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- triglyceride catabolic process [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.
FoxO1, a forkhead box O class transcription factor, is abundant in insulin-responsive tissues. Akt, downstream from phosphatidylinositol 3-kinase in insulin signaling, phosphorylates FoxO1 at Thr(24), Ser(256), and Ser(319), negatively regulating its function. We previously reported that dehydroepiandrosterone-stimulated phosphorylation of FoxO1 in endothelial cells requires cAMP-dependent protein kinase α (PKA-α). Therefore, we hypothesized that FoxO1 is a novel direct substrate for ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKACA FOXO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1527940 | |
| PRKACA FOXO1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1527938 |
Curated By
- BioGRID