ARNT
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- mRNA transcription from RNA polymerase II promoter [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to hypoxia [IDA]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
TUBB2A
Gene Ontology Biological Process
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Beta tubulin affects the aryl hydrocarbon receptor function via an Arnt-mediated mechanism.
We have been studying the requirement for the aryl hydrocarbon receptor nuclear translocator (Arnt)-dependent DNA complex formation, which precedes the activation of gene transcription. Using DEAE chromatography, we have obtained a Sf9 insect fraction F5 that is highly enriched with beta-tubulin. F5 inhibits the formation of the AhR gel shift complex and this inhibition is sensitive to protease, suggesting that ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Curated By
- BioGRID