MAVS
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- cellular response to exogenous dsRNA [IMP]
- defense response to bacterium [IMP]
- defense response to virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of IP-10 production [IDA]
- positive regulation of chemokine (C-C motif) ligand 5 production [IDA]
- positive regulation of defense response to virus by host [IDA, IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of protein import into nucleus, translocation [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- regulation of peroxisome organization [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CSNK1E
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The kinase CK1É› controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
The signaling adaptor TRAF3 is a highly versatile regulator of both innate immunity and adaptive immunity, but how its phosphorylation is regulated is still unknown. Here we report that deficiency in or inhibition of the conserved serine-threonine kinase CK1É› suppressed the production of type I interferon in response to viral infection. CK1É› interacted with and phosphorylated TRAF3 at Ser349, which ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID