BAIT
UNC45A
GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A
unc-45 homolog A (C. elegans)
GO Process (0)
GO Function (0)
GO Component (3)
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90AB1
D6S182, HSP84, HSP90B, HSPC2, HSPCB, RP1-302G2.1
heat shock protein 90kDa alpha (cytosolic), class B member 1
GO Process (9)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- regulation of interferon-gamma-mediated signaling pathway [IMP]
- regulation of type I interferon-mediated signaling pathway [IMP]
- response to unfolded protein [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.
Hsp90 is an essential molecular chaperone required for the normal functioning of many key regulatory proteins in eukaryotic cells. Vertebrates have two closely related isoforms of cytosolic Hsp90 (Hsp90alpha and Hsp90beta). However, specific functions for each isoform are largely unknown, and no Hsp90 co-chaperone has been reported to distinguish between the two isoforms. In this study, we show that the ... [more]
J. Biol. Chem. Apr. 11, 2008; 283(15);9509-12 [Pubmed: 18285346]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Curated By
- BioGRID