BAIT
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
GO Process (83)
GO Function (22)
GO Component (16)
Gene Ontology Biological Process
- activation of protein kinase B activity [IMP]
- adherens junction organization [IDA]
- bone resorption [IBA, ISO, ISS]
- branching involved in mammary gland duct morphogenesis [ISO]
- cell migration [ISO]
- cell proliferation [IDA]
- cellular response to fatty acid [IEP]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- cellular response to progesterone stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [IEP]
- forebrain development [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO]
- intracellular estrogen receptor signaling pathway [IBA]
- intracellular signal transduction [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitochondrial depolarization [ISO]
- negative regulation of protein homooligomerization [ISO]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [IDA]
- oogenesis [ISO]
- osteoclast development [IBA, ISO]
- peptidyl-serine phosphorylation [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of apoptotic process [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell adhesion [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- positive regulation of cytokine secretion [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of platelet-derived growth factor receptor signaling pathway [IEP]
- positive regulation of podosome assembly [ISO]
- positive regulation of protein autophosphorylation [IMP]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein transport [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- progesterone receptor signaling pathway [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO]
- regulation of caveolin-mediated endocytosis [ISO]
- regulation of cell projection assembly [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell-cell adhesion [ISO]
- regulation of early endosome to late endosome transport [ISO]
- regulation of epithelial cell migration [ISO]
- regulation of intracellular estrogen receptor signaling pathway [ISO]
- regulation of podosome assembly [IBA]
- regulation of protein binding [ISO]
- response to acidic pH [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to fatty acid [IEP]
- response to hydrogen peroxide [IEP]
- response to interleukin-1 [ISO]
- response to mechanical stimulus [IEP]
- response to mineralocorticoid [IEP]
- response to nutrient levels [IEP]
- response to virus [IEP]
- single organismal cell-cell adhesion [IEP]
- stress fiber assembly [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transcytosis [IDA]
- transforming growth factor beta receptor signaling pathway [ISO]
- uterus development [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- cell adhesion molecule binding [IPI]
- enzyme binding [IPI, ISO]
- ephrin receptor binding [ISO]
- estrogen receptor binding [IPI]
- growth factor receptor binding [IBA, ISO]
- heme binding [ISO, ISS]
- insulin receptor binding [IPI]
- ion channel binding [ISO]
- kinase activity [ISO, TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI, ISO]
- scaffold protein binding [ISO]
- SH2 domain binding [ISO]
- cell adhesion molecule binding [IPI]
- enzyme binding [IPI, ISO]
- ephrin receptor binding [ISO]
- estrogen receptor binding [IPI]
- growth factor receptor binding [IBA, ISO]
- heme binding [ISO, ISS]
- insulin receptor binding [IPI]
- ion channel binding [ISO]
- kinase activity [ISO, TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI, ISO]
- scaffold protein binding [ISO]
Gene Ontology Cellular Component
- actin filament [ISO]
- caveola [IDA, ISO]
- cytoplasm [ISO]
- cytosol [ISO, NAS, TAS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- intracellular [ISO]
- late endosome [ISO]
- lysosome [ISO]
- mitochondrial inner membrane [ISO, ISS]
- mitochondrion [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- ruffle membrane [ISO]
Rattus norvegicus
PREY
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
GO Process (83)
GO Function (22)
GO Component (16)
Gene Ontology Biological Process
- activation of protein kinase B activity [IMP]
- adherens junction organization [IDA]
- bone resorption [IBA, ISO, ISS]
- branching involved in mammary gland duct morphogenesis [ISO]
- cell migration [ISO]
- cell proliferation [IDA]
- cellular response to fatty acid [IEP]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- cellular response to progesterone stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [IEP]
- forebrain development [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO]
- intracellular estrogen receptor signaling pathway [IBA]
- intracellular signal transduction [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitochondrial depolarization [ISO]
- negative regulation of protein homooligomerization [ISO]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [IDA]
- oogenesis [ISO]
- osteoclast development [IBA, ISO]
- peptidyl-serine phosphorylation [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of apoptotic process [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell adhesion [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- positive regulation of cytokine secretion [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of platelet-derived growth factor receptor signaling pathway [IEP]
- positive regulation of podosome assembly [ISO]
- positive regulation of protein autophosphorylation [IMP]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein transport [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- progesterone receptor signaling pathway [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO]
- regulation of caveolin-mediated endocytosis [ISO]
- regulation of cell projection assembly [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell-cell adhesion [ISO]
- regulation of early endosome to late endosome transport [ISO]
- regulation of epithelial cell migration [ISO]
- regulation of intracellular estrogen receptor signaling pathway [ISO]
- regulation of podosome assembly [IBA]
- regulation of protein binding [ISO]
- response to acidic pH [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to fatty acid [IEP]
- response to hydrogen peroxide [IEP]
- response to interleukin-1 [ISO]
- response to mechanical stimulus [IEP]
- response to mineralocorticoid [IEP]
- response to nutrient levels [IEP]
- response to virus [IEP]
- single organismal cell-cell adhesion [IEP]
- stress fiber assembly [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transcytosis [IDA]
- transforming growth factor beta receptor signaling pathway [ISO]
- uterus development [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- cell adhesion molecule binding [IPI]
- enzyme binding [IPI, ISO]
- ephrin receptor binding [ISO]
- estrogen receptor binding [IPI]
- growth factor receptor binding [IBA, ISO]
- heme binding [ISO, ISS]
- insulin receptor binding [IPI]
- ion channel binding [ISO]
- kinase activity [ISO, TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI, ISO]
- scaffold protein binding [ISO]
- SH2 domain binding [ISO]
- cell adhesion molecule binding [IPI]
- enzyme binding [IPI, ISO]
- ephrin receptor binding [ISO]
- estrogen receptor binding [IPI]
- growth factor receptor binding [IBA, ISO]
- heme binding [ISO, ISS]
- insulin receptor binding [IPI]
- ion channel binding [ISO]
- kinase activity [ISO, TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI, ISO]
- scaffold protein binding [ISO]
Gene Ontology Cellular Component
- actin filament [ISO]
- caveola [IDA, ISO]
- cytoplasm [ISO]
- cytosol [ISO, NAS, TAS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- intracellular [ISO]
- late endosome [ISO]
- lysosome [ISO]
- mitochondrial inner membrane [ISO, ISS]
- mitochondrion [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- ruffle membrane [ISO]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases.
Cyclooxygenases (COXs) are crucial rate-limiting enzymes required for the biosynthesis of prostaglandins. COX-2 is an inducible isoform of this enzyme, which is believed to play important roles in the development of atherosclerotic vascular disease. We found that COX-2 expression rapidly increases in response to various signaling events, including activation of the platelet-derived growth factor (PDGF) pathway. Activation of PDGF receptor ... [more]
J. Biol. Chem. Nov. 09, 2007; 282(45);32699-709 [Pubmed: 17855367]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRC SRC | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1059767 |
Curated By
- BioGRID