PRDX6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SFTPA1
Gene Ontology Biological Process
- cellular response to mechanical stimulus [IEP]
- cellular response to nitric oxide [IEP]
- circadian rhythm [IEP]
- positive regulation of phagocytosis [IDA]
- response to epidermal growth factor [IEP]
- response to glucocorticoid [IEP]
- response to hormone [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to interleukin-6 [IEP]
- response to lipopolysaccharide [IEP]
- response to retinoic acid [IEP]
- response to vitamin A [IEP]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.
Peroxiredoxin 6 (Prdx6) is a "moonlighting" protein with both GSH peroxidase and phospholipase A(2) (PLA(2)) activities. This protein is responsible for degradation of internalized dipalmitoylphosphatidylcholine, the major phospholipid component of lung surfactant. The PLA(2) activity is inhibited by surfactant protein A (SP-A). We postulate that SP-A regulates the PLA(2) activity of Prdx6 through direct protein-protein interaction. Recombinant human Prdx6 and ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 7
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SFTPA1 PRDX6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1528447 |
Curated By
- BioGRID