Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery.
Bacterial protein synthesis is an essential, conserved, and environmentally responsive process. Yet, many of its components and dependencies remain unidentified. To address this gap, we used quantitative synthetic genetic arrays to map functional relationships among >48,000 gene pairs in Escherichia coli under four culture conditions differing in temperature and nutrient availability. The resulting data provide global functional insights into the roles and ... [more]
Cell Rep Oct. 11, 2016; 17(3);904-916 [Pubmed: 27732863]
Quantitative Score
- 0.221987811 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Conditions: Rich Media 32Deg C
- Genetic interactions were considered significant if they had an Epsilon score >= 0.153831326 for positive interactions (alleviating interactions) and Epsilon score <= -0.099945541 for negative interactions (aggravating interactions).
Curated By
- BioGRID