NFATC1
Gene Ontology Biological Process
Gene Ontology Molecular Function- FK506 binding [TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- RNA polymerase II transcription factor binding [ISS]
- mitogen-activated protein kinase p38 binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription regulatory region DNA binding [IDA]
- FK506 binding [TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- RNA polymerase II transcription factor binding [ISS]
- mitogen-activated protein kinase p38 binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
SCAI
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Novel Nuclear Factor of Activated T Cells (NFAT)-Associated Proteins in T cells.
Transcription factors of the nuclear factor of activated T cell (NFAT)-family are essential for antigen-specific T cell activation and differentiation. Their cooperative DNA binding with other transcription factors, such as AP1-proteins (FOS, JUN, JUNB), FOXP3, IRFs and EGR1, dictate the gene regulatory action of NFATs. To identify as yet unknown interaction partners of NFAT, we purified biotin tagged NFATc1/αA, NFATc1/βC ... [more]
Quantitative Score
- 22.1 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- The score displays the factor of enrichment of the prey protein. It is a ratio of the prey protein's abundance in CoIP-MS when the bait protein was present versus its abundance in control experiments without bait protein. The shown values are means from >= 2 experiments.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFATC1 SCAI | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID