NFATC2
Gene Ontology Biological Process
- B cell receptor signaling pathway [IMP]
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration [IDA]
- cellular response to DNA damage stimulus [IMP]
- innate immune response [TAS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [TAS]
- response to drug [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- cytoplasm [IDA, TAS]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, TAS]
- plasma membrane [IDA]
WDR48
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Novel Nuclear Factor of Activated T Cells (NFAT)-Associated Proteins in T cells.
Transcription factors of the nuclear factor of activated T cell (NFAT)-family are essential for antigen-specific T cell activation and differentiation. Their cooperative DNA binding with other transcription factors, such as AP1-proteins (FOS, JUN, JUNB), FOXP3, IRFs and EGR1, dictate the gene regulatory action of NFATs. To identify as yet unknown interaction partners of NFAT, we purified biotin tagged NFATc1/αA, NFATc1/βC ... [more]
Quantitative Score
- 9.4 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- The score displays the factor of enrichment of the prey protein. It is a ratio of the prey protein's abundance in CoIP-MS when the bait protein was present versus its abundance in control experiments without bait protein. The shown values are means from >= 2 experiments.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFATC2 WDR48 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID