BAIT
NFATC1
NF-ATC, NFAT2, NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
GO Process (6)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function- FK506 binding [TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- RNA polymerase II transcription factor binding [ISS]
- mitogen-activated protein kinase p38 binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription regulatory region DNA binding [IDA]
- FK506 binding [TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- RNA polymerase II transcription factor binding [ISS]
- mitogen-activated protein kinase p38 binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
FXR1
FXR1P
fragile X mental retardation, autosomal homolog 1
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Novel Nuclear Factor of Activated T Cells (NFAT)-Associated Proteins in T cells.
Transcription factors of the nuclear factor of activated T cell (NFAT)-family are essential for antigen-specific T cell activation and differentiation. Their cooperative DNA binding with other transcription factors, such as AP1-proteins (FOS, JUN, JUNB), FOXP3, IRFs and EGR1, dictate the gene regulatory action of NFATs. To identify as yet unknown interaction partners of NFAT, we purified biotin tagged NFATc1/αA, NFATc1/βC ... [more]
J. Biol. Chem. Sep. 16, 2016; 0(0); [Pubmed: 27637333]
Quantitative Score
- 5.1 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- The score displays the factor of enrichment of the prey protein. It is a ratio of the prey protein's abundance in CoIP-MS when the bait protein was present versus its abundance in control experiments without bait protein. The shown values are means from >= 2 experiments.
Curated By
- BioGRID