PREY

TRIM27

RFP, RNF76, DAAP-182E11.3
tripartite motif containing 27
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

Rodrigo-Brenni MC, Gutierrez E, Hegde RS

Approximately 30% of eukaryotic proteins contain hydrophobic signals for localization to the secretory pathway. These proteins can be mislocalized in the cytosol due to mutations in their targeting signals, certain stresses, or intrinsic inefficiencies in their translocation. Mislocalized proteins (MLPs) are protected from aggregation by the Bag6 complex and degraded by a poorly characterized proteasome-dependent pathway. Here, we identify the ... [more]

Mol. Cell Jul. 17, 2014; 55(2);227-37 [Pubmed: 24981174]

Throughput

  • Low Throughput

Curated By

  • BioGRID