SMURF1
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- cell differentiation [IDA]
- ectoderm development [TAS]
- negative regulation of BMP signaling pathway [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein export from nucleus [IDA]
- protein localization to cell surface [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- receptor catabolic process [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CALCOCO1
Gene Ontology Biological Process
Gene Ontology Molecular Function- armadillo repeat domain binding [IPI]
- beta-catenin binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IMP, ISS]
- transcription cofactor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IMP, ISS]
- transcription cofactor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.
The ubiquitin proteasome pathway (UPP) has been implicated in a number of pathogenic diseases: cancer, inflammation, metabolic disorders, and viral infection. The human genome contains well over 500 genes encoding proteins involved in the UPP. Ubiquitin ligases (E3s) comprise the largest subset of these genes, and together with an E2 partner, provide the substrate selectivity required for regulating cellular proteins ... [more]
Throughput
- High Throughput
Additional Notes
- peptide in vitro array
Curated By
- BioGRID