PPARD
Gene Ontology Biological Process
- apoptotic signaling pathway [IMP]
- axon ensheathment [ISS]
- cell proliferation [ISS, TAS]
- cholesterol metabolic process [TAS]
- decidualization [TAS]
- embryo implantation [TAS]
- fatty acid beta-oxidation [ISS, TAS]
- fatty acid catabolic process [TAS]
- fatty acid transport [ISS]
- gene expression [TAS]
- generation of precursor metabolites and energy [TAS]
- glucose metabolic process [NAS]
- glucose transport [NAS]
- intracellular receptor signaling pathway [IDA]
- lipid metabolic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of fat cell differentiation [NAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [NAS]
PEBP1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of acetylcholine metabolic process [ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of mitosis [ISO]
- regulation of neurotransmitter levels [ISO]
- regulation of the force of heart contraction [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- apical part of cell [ISO]
- axon terminus [ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- rough endoplasmic reticulum [ISO]
- synaptic vesicle [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.
We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice. PPARs belong to the nuclear receptor superfamily. They form heterodimer with a retinoid X receptor, recruit transcriptional cofactors, and bind to a specific recognition element for regulation of target genes. Although cofactors are generally shared by various nuclear ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID