BAIT
LPAR2
EDG-4, EDG4, LPA-2, LPA2
lysophosphatidic acid receptor 2
GO Process (2)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC9A3R2
E3karp
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
GO Process (4)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.
Lysophosphatidic acid (LPA) activates a family of cognate G protein-coupled receptors and is involved in various pathophysiological processes. However, it is not clearly understood how these LPA receptors are specifically coupled to their downstream signaling molecules. This study found that LPA(2), but not the other LPA receptor isoforms, specifically interacts with Na(+)/H(+) exchanger regulatory factor2 (NHERF2). In addition, the interaction ... [more]
Mol. Cell. Biol. Jun. 01, 2004; 24(11);5069-79 [Pubmed: 15143197]
Throughput
- Low Throughput
Additional Notes
- Figure 1
Curated By
- BioGRID