MAPKAPK2
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [ISO]
- G2 DNA damage checkpoint [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- inflammatory response [IMP]
- inner ear development [IDA]
- mRNA stabilization [IMP]
- macropinocytosis [IMP]
- peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [IDA]
- regulation of interleukin-6 production [IMP]
- regulation of tumor necrosis factor production [IMP, ISO]
- response to cytokine [ISO]
- response to lipopolysaccharide [IMP]
- response to stress [ISO]
- toll-like receptor signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPB1
Gene Ontology Biological Process
- cellular response to vascular endothelial growth factor stimulus [ISO]
- intracellular signal transduction [ISO]
- negative regulation of apoptotic signaling pathway [IDA]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- platelet aggregation [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of endothelial cell chemotaxis [ISO]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of interleukin-1 beta production [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- response to unfolded protein [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Role of p38alpha Map kinase in Type I interferon signaling.
Multiple signaling pathways are activated during engagement of the Type I interferon (IFN) receptor to mediate biological responses, including the Jak-Stat and Rac1/p38 Map kinase signaling cascades. In the present study we sought to determine the functional relevance of the p38alpha isoform in IFN signaling, using cells from mouse embryos with targeted disruption of the p38alpha gene. Our data demonstrate ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 7
Curated By
- BioGRID