BAIT

MAPKAPK3

3PK, AI874665, MAPKAP-K3, MAPKAP3, MK-3, MK3, MapkKapk3, RP23-115A1.1

mitogen-activated protein kinase-activated protein kinase 3

GO Process (5)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

macropinocytosis [IMP]

peptidyl-serine phosphorylation [ISO]

response to cytokine [ISO]

response to lipopolysaccharide [IMP]

toll-like receptor signaling pathway [IMP]

Gene Ontology Molecular Function

protein serine/threonine kinase activity [ISO]

Gene Ontology Cellular Component

cytoplasm [ISO]

nuclear membrane [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

HSPB1

27kDa, Hsp25

heat shock protein 1

GO Process (15)

GO Function (6)

GO Component (10)

Gene Ontology Biological Process

cellular response to vascular endothelial growth factor stimulus [ISO]

intracellular signal transduction [ISO]

negative regulation of apoptotic signaling pathway [IDA]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]

negative regulation of protein kinase activity [IDA]

negative regulation of protein serine/threonine kinase activity [IDA]

platelet aggregation [ISO]

positive regulation of angiogenesis [ISO]

positive regulation of blood vessel endothelial cell migration [ISO]

positive regulation of endothelial cell chemotaxis [ISO]

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]

positive regulation of interleukin-1 beta production [IDA]

positive regulation of tumor necrosis factor biosynthetic process [IDA]

regulation of I-kappaB kinase/NF-kappaB signaling [IDA]

response to unfolded protein [NAS]

Gene Ontology Molecular Function

identical protein binding [ISO]
poly(A) RNA binding [ISO]
protein kinase C binding [IDA]
protein kinase C inhibitor activity [IDA]
protein kinase binding [ISO]
ubiquitin binding [ISO]

Gene Ontology Cellular Component

contractile fiber [IDA]

cytoplasm [IDA, ISO]

extracellular space [ISO]

extracellular vesicular exosome [ISO]

focal adhesion [ISO]

intracellular [IDA]

nucleus [IDA, ISO]

plasma membrane [IDA]

proteasome complex [ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Role of p38alpha Map kinase in Type I interferon signaling.

Li Y, Sassano A, Majchrzak B, Deb DK, Levy DE, Gaestel M, Nebreda AR, Fish EN, Platanias LC

Multiple signaling pathways are activated during engagement of the Type I interferon (IFN) receptor to mediate biological responses, including the Jak-Stat and Rac1/p38 Map kinase signaling cascades. In the present study we sought to determine the functional relevance of the p38alpha isoform in IFN signaling, using cells from mouse embryos with targeted disruption of the p38alpha gene. Our data demonstrate ... [more]

J. Biol. Chem. Jan. 09, 2004; 279(2);970-9 [Pubmed: 14578350]

Throughput

Low Throughput

Additional Notes

Figure 7

Curated By

BioGRID