MAP2K1
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- MAPK cascade [IMP, ISO]
- activation of MAPK activity [IDA, ISO, TAS]
- cell cycle arrest [ISO]
- cell motility [ISO]
- cell proliferation [IDA]
- cellular senescence [ISO]
- intracellular signal transduction [TAS]
- keratinocyte differentiation [ISO]
- labyrinthine layer development [ISO]
- melanosome transport [IDA]
- mitotic nuclear division [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of homotypic cell-cell adhesion [IMP]
- neuron differentiation [IMP, ISO]
- neuron projection morphogenesis [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- placenta blood vessel development [ISO]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of Ras protein signal transduction [IMP]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- protein heterooligomerization [IPI]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- regulation of vascular smooth muscle contraction [IMP]
- response to axon injury [IMP]
- response to glucocorticoid [IDA]
- response to oxidative stress [IDA]
- vesicle transport along microtubule [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, TAS]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- cytosol [IDA, TAS]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [IDA]
- mitochondrion [TAS]
- nucleus [TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
MBP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.
TAK1, a member of the mitogen-activated kinase kinase kinase (MAPKKK) family, participates in proinflammatory cellular signaling pathways by activating JNK/p38 MAPKs and NF-kappaB. To identify drugs that prevent inflammation, we screened inhibitors of TAK1 catalytic activity. We identified a natural resorcylic lactone of fungal origin, 5Z-7-oxozeaenol, as a highly potent inhibitor of TAK1. This compound did not effectively inhibit the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID