LIPE
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLIN5
Gene Ontology Biological Process
- lipid particle organization [ISS]
- negative regulation of fatty acid beta-oxidation [ISS]
- negative regulation of lipase activity [ISS]
- negative regulation of peroxisome proliferator activated receptor signaling pathway [ISS]
- negative regulation of reactive oxygen species metabolic process [ISS]
- negative regulation of triglyceride catabolic process [ISS]
- positive regulation of fatty acid beta-oxidation [ISS]
- positive regulation of lipase activity [ISS]
- positive regulation of lipid storage [ISS]
- positive regulation of sequestering of triglyceride [ISS]
- positive regulation of triglyceride biosynthetic process [ISS]
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins.
Lipolysis is an important metabolic pathway controlling energy homeostasis through degradation of triglycerides stored in lipid droplets and release of fatty acids. Lipid droplets of mammalian cells are coated with one or more members of the PAT protein family, which serve important functions in regulating lipolysis. In this study, we investigate the mechanisms by which PAT family members, perilipin A, ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LIPE PLIN5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1536837 |
Curated By
- BioGRID