MPH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
REV1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-action of the Mph1 DNA Helicase.
Mutations that cause genome instability are considered important predisposing events that contribute to initiation and progression of cancer. Genome instability arises either due to defects in genes that cause an increased mutation rate (mutator phenotype) or defects in genes that cause chromosome instability (CIN). To extend the catalogue of genome instability genes, we systematically explored the effects of gene over-expression ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mutation frequency (APO:0000198)
Additional Notes
- Removal of REV3 together with REV1 or RAD30 partially reduced the frequency of CANR mutants caused by overepxression of Mph1
- genetic complex
- suppressing
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
REV1 MPH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1486 | BioGRID | 2187512 | |
REV1 MPH1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 161185 |
Curated By
- BioGRID