MMS1
Gene Ontology Biological Process
Gene Ontology Cellular Component
MPH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-action of the Mph1 DNA Helicase.
Mutations that cause genome instability are considered important predisposing events that contribute to initiation and progression of cancer. Genome instability arises either due to defects in genes that cause an increased mutation rate (mutator phenotype) or defects in genes that cause chromosome instability (CIN). To extend the catalogue of genome instability genes, we systematically explored the effects of gene over-expression ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- enhancing
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MMS1 MPH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.0822 | BioGRID | 2604943 | |
MMS1 MPH1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0752 | BioGRID | 2605132 |
Curated By
- BioGRID