CDC13
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC20
Gene Ontology Biological Process
- activation of anaphase-promoting complex activity involved in meiotic cell cycle [IMP]
- activation of mitotic anaphase-promoting complex activity [IMP]
- mitotic spindle assembly checkpoint [IPI]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- positive regulation of protein catabolic process [IMP]
- regulation of meiosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Cdc20, a beta-transducin homologue, links RAD9-mediated G2/M checkpoint control to mitosis in Saccharomyces cerevisiae.
In the budding yeast Saccharomyces cerevisiae, the DNA damage-induced G2 arrest requires the checkpoint control genes RAD9, RAD17, RAD24, MEC1, MEC2 and MEC3. These genes also prevent entry into mitosis of a temperature-sensitive mutant, cdc13, that accumulates chromosome damage at 37 degrees C. Here we show that a cdc13 mutant overexpressing Cdc20, a beta-transducin homologue, no longer arrests in G2 ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression (APO:0000253)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CDC13 CDC20 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2283 | BioGRID | 1924641 | |
CDC20 CDC13 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3177 | BioGRID | 1933165 |
Curated By
- BioGRID