BAIT

SST2

GTPase-activating protein SST2, L000002093, YLR452C
GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
GO Process (2)
GO Function (1)
GO Component (1)
Saccharomyces cerevisiae (S288c)
PREY

CSN9

S000007578, YDR179C
Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
GO Process (2)
GO Function (0)
GO Component (1)
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae.

Maytal-Kivity V, Piran R, Pick E, Hofmann K, Glickman MH

A family of genetically and structurally homologous complexes, the proteasome lid, Cop9 signalosome (CSN) and eukaryotic translation initiation factor 3, mediate different regulatory pathways. The CSN functions in numerous eukaryotes as a regulator of development and signaling, yet until now no evidence for a complex has been found in Saccharomyces cerevisiae. We identified a group of proteins, including a homolog ... [more]

EMBO Rep. Dec. 01, 2002; 3(12);1215-21 [Pubmed: 12446563]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: pheromone sensitivity (APO:0000037)
  • phenotype: pheromone-induced cell cycle arrest (APO:0000124)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CSN9 SST2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1373BioGRID
2096998
SST2 CSN9
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
657329

Curated By

  • BioGRID