BAIT

ZEB1

AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A, RP11-472N13.4
zinc finger E-box binding homeobox 1
Homo sapiens
PREY

DRAP1

NC2-alpha
DR1-associated protein 1 (negative cofactor 2 alpha)
GO Process (0)
GO Function (3)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.

Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K

The transcription factor AREB6 contains a homeodomain flanked by two clusters of Krueppel type C2H2 zinc fingers. AREB6 binds to the E-box consensus sequence, CACCTGT, through either the N- or the C-terminal zinc finger cluster. To gain insights into the molecular mechanism by which AREB6 activates and represses gene expression, we analyzed the domain structure of AREB6 in the context ... [more]

Mol. Cell. Biol. Jan. 01, 1998; 18(1);10-8 [Pubmed: 9418848]

Throughput

  • Low Throughput

Curated By

  • BioGRID