BAIT

KRE9

L000000916, YJL174W
Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

KNH1

L000002837, YDL049C
Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9.

Dijkgraaf GJ, Brown JL, Bussey H

The KNH1 gene from Saccharomyces cerevisiae was identified as an open reading frame on the right arm of chromosome IV. The product encoded by the KNH1 gene, Knhlp, shares 46% overall identity with Kre9p, a protein required for cell surface beta 1,6-glucan synthesis. While disruption of the KNH1 locus had no effect on cell growth, killer toxin sensitivity or beta ... [more]

Yeast Jun. 15, 1996; 12(7);683-92 [Pubmed: 8810042]

Throughput

  • Low Throughput

Ontology Terms

  • vegetative growth (APO:0000106)
  • chemical compound accumulation (APO:0000095)

Additional Notes

  • overexpression of KNH1 suppresses the severe growth defect of a kre9 mutant and restores the level of alkali-insoluble beta 1,6-glucan to almost wild-type levels

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
KNH1 KRE9
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
158194
KNH1 KRE9
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

High-BioGRID
112614
KRE9 KNH1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

High-BioGRID
112615

Curated By

  • BioGRID