MIG1
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IDA, IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
Gene Ontology Molecular Function
PDE2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells.
Cyclin C and the cyclin C-dependent protein kinase are associated with the RNA polymerase II Mediator complex, which regulates initiation of transcription in response to signals from activators and repressors bound to upstream promoter elements. Disruption of the corresponding genes, SRB11 and SRB10, in budding yeast causes a reduction in expression of the GAL genes, which is particularly pronounced in ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: utilization of carbon source (APO:0000098)
- phenotype: utilization of carbon source (APO:0000098)
Additional Notes
- Overexpression of PDE2 can rescue growth in an snf1/mig1/gis4 triple mutant
- Pde2 rescues the growth of an Snf1/Mig1/Srb11 triple mutant on galactose
- genetic complex
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PDE2 MIG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
MIG1 PDE2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 520755 |
Curated By
- BioGRID