TFC8
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding, bending [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- DNA binding, bending [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
Gene Ontology Cellular Component
TFC1
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding, bending [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- DNA binding, bending [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein.
TFIIIC plays a key role in nucleating the assembly of the initiation factor TFIIIB on class III genes. We have characterized an essential gene, TFC8, encoding the 60-kDa polypeptide, tau60, present in affinity-purified TFIIIC. Hemagglutinin-tagged variants of tau60 were found to be part of TFIIIC-tDNA complexes and to reside at least in part in the downstream DNA-binding domain tauB. Unexpectedly, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: temperature sensitive growth (APO:0000092)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TFC1 TFC8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| TFC1 TFC8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| TFC8 TFC1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| TFC1 TFC8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| TFC1 TFC8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 6 | BioGRID | 3605460 | |
| TFC8 TFC1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2844 | BioGRID | 1954523 | |
| TFC1 TFC8 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4937 | BioGRID | 1921009 |
Curated By
- BioGRID