BAIT

UTH1

SUN family protein UTH1, L000002766, YKR042W
Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)
PREY

SIM1

putative glucosidase SIM1, L000003937, YIL123W
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity.

Mouassite M, Guerin MG, Camougrand NM

UTH1 and SIM1 are two of four 'SUN' genes (SIM1, UTH1, NCA3 and SUN4/SCW3) whose products are involved in different cellular processes such as DNA replication, lifespan, mitochondrial biogenesis or cell septation. UTH1 or SIM1 inactivation did not affect cell growth, shape or nuclear migration, whereas the double null mutant presented phenotypes of numerous binucleate cells and benomyl sensitivity, suggesting ... [more]

FEMS Microbiol. Lett. Jan. 01, 2000; 182(1);137-41 [Pubmed: 10612745]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: utilization of carbon source (APO:0000098)
  • phenotype: nuclear morphology (APO:0000057)
  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: stress resistance (APO:0000080)
  • phenotype: survival rate in stationary phase (APO:0000109)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
UTH1 SIM1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.742BioGRID
395233
SIM1 UTH1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.8938BioGRID
2132815
UTH1 SIM1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-21.2307BioGRID
901119

Curated By

  • BioGRID